مشخصات پژوهش

The first metal organic framework based on phthalocyanine was synthesized (MOF P). A green synthesis route was employed to fabricate zinc oxide (ZnO) nanoparticles using Amaranthus spinosus extract. The as-synthesized ZnO was subsequently integrated into MOF P, yielding a novel MOF P/ZnO nanocomposite. It was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Fourier transform infra-red spectroscopy (FT-IR), Energy dispersive X-ray analysis (EDAX), elemental analysis, and Ultravioletvisible (UV-Vis) spectroscopy. This study demonstrates a novel therapeutic platform based on phthalocyanine-integrated metal-organic frameworks (MOFs) and ZnO nanoparticles for targeted and efficient cancer therapy. MTT assay results demonstrated a dose-dependent reduction in cell viability following MOF P/ZnO treatment. Flow cytometry analysis of apoptosis revealed a marked increase in early and late apoptotic cells. Moreover, ROS levels were significantly elevated in treated cells.