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عنوان
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Reaction of α-oxoketenes with 2-substituted benzothiazoles
and benzimidazoles: synthesis of benzo[4,5]thiazolo[3,2-a]pyridinone
and N-(1,3-benzothiazol-2-yl)-3-oxopropanamide derivatives
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کلیدواژهها
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chlorocarbonyl phenyl ketene, 1,3-dioxin-4-ones, Meldrum's acids, α-oxoketenes, 2-substituted benzothiazoles.
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چکیده
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A fast and simple procedure for the synthesis of pyrimidinone derivatives via the cyclocondensation reactions of α-oxoketenes with
2-substituted benzothiazoles have been investigated. Acyl-substituted Meldrum's acids and 1,3-dioxin-4-one derivatives have been used
as starting compounds for preparation of α-oxoketenes, which were used in the cycloaddition reactions with (benzothiazol-2-yl)-
acetonitrile and (benzimidazol-2-yl)acetonitrile giving good product yields. Also the reaction of (chlorocarbonyl)phenylketene with
2-(1,3-benzothiazol-2-yl)acetonitrile has been investigated.
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