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Abstract
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the present study, a magnetic nano gel as
the sorbent which is the combination of octatonic acid:
cumarin as eutectic solvent and Fe3O4@
SiO2 was introduced
as the sorbent in ultrasound-assisted dispersive μ-solid
phase extraction process coupled with high performance
liquid chromatography with photo diode array detector
for simultaneous separation and determination of tetracyclines
residues in food samples. FT-IR, SEM, VSM were
used for the characterization of the synthetized magnetic
nano gel. Under obtained optimum conditions, the obtained
linear ranges were 1.5–500 (μg L−
1), 2.5–750 (μg L−
1),
2–750 (μg L−
1), and 2.5–500 (μg L−
1) for tetracycline,
oxytetracycline, chlortetracycline, and doxycycline, respectively.
Moreover, the below level of quantification (BLQ)
(based on S/N = 3) of 0.47 μg L−
1, 0.11 μg L−
1, 0.85 μg L−
1,
0.66 μg L−
1, 0.81 μg L−
1 and the limit of quantification
(based on S/N = 10) of 1.61, 2.74, 2.23 (μg L−
1), and 2.66
were achieved for tetracycline, oxytetracycline, chlortetracycline,
and doxycycline, respectively. The intra-day and
inter-day precision (%) of the procedure were less than 3.2
and 3.8, respectively. The recoveries over 95% confirmed
high sufficiency of the proposed method for application in
complex matrices such as honey, milk, and egg.
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