In this study, the efficiency of g-C3N4-oxidized nanocellulose for removing paracetamol in aqueous solution was evaluated. The experiments were performed in various conditions of solution pH, contact time, initial concentration, adsorbent concentration for the adsorption of paracetamol on g-C3N4-oxidized nanocellulose. The central composite design (CCD)–based response surface methodology (RSM) was employed to design the experiments and find optimal conditions.