Abdollah Ramazani

Diabetes mellitus is a serious medical problem that the outbreak is increasing all over the world [1]. The present study investigates the effects of aqueous suspension of dried latex of Calotropis procera with vitamin C in diabetic rats. Diabetes was induced intraperitoneally (IP) in rats by a single dose of streptozotocin (50 mg/kg b.w). Thirty adult male Wistar rats with approximate weight of 180-200 gr were randomly and equally divided into six groups as follow: first group) control, second group) diabetic rats, third group) include diabetic mice that were treated by 200 mg dried latex per kilogram of body weight, the fourth group) the diabetic rats of this group were treated by combined treatments of dried latex of 200 mg/kg and vitamin C of 100mg/kg b.w by gavage, fifth group) animals in this group were treated by 200 mg/kg b.w dried latex by gavage and the sixth group) includes rats were treated by 100mg/kg b.w vitamin C by gavage daily. At the end of 15 days, the biochemical factors of blood sugar, total cholestrol were studied after direct anesthetizing of animals and blood samples were taken from the heart. According to the studies, the amount of blood sugar, total cholestrol were increased significantly in diabetic group. But the treatment of diabetic group by aqueous extract of dried latex and also the combined treatments of aqueous extract of dried latex and vitamin C improved and reduced the above biochemical factors significantly. The results of this research work showed that the aqueous extract of dried latex compared to the group four, had a better effect in reduction of serum biochemical factors. The conclusion is that the dried latex of Calotropis procera could therefore play important role in reducing diabetic complications in type 1 diabetes.