University of Jiroft | Abdollah Ramazani

Research

Title	Monoclonal antibodies as tumor targeting agents in multiple myeloma
Type	Presentation
Keywords	Monocolonal antibodies, targeting peptide, multiple myeloma, conformational study
Researchers	Abdollah Ramazani, Fereshteh Ezzatighadi

Abstract

Abstract Multiple myeloma (MM) is a hematological malignancy that remains incurable because most patients will eventually relapse or become refractory to the treatments. Novel agents are currently in development for the treatment of relapsed/refractory MM, including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, cell signaling targeted therapies, and strategies targeting the tumor microenvironment. for this purpose the conformational structure of the hexapeptide H3N+-FDDARL-COO-, H3N+-FVDVRLCOO-, H3N+-FSDARL-COO- has been investigated by the PCILO method. The computational results show this tree structure have no functionality group for bind to M protein. Moreover, H3N+-FVDVRL-COO- has assumes the somewhat amphipathic structure.