Weed management is crucial for sustainable crop production, and chemical herbicides are widely utilized for weed control in developed countries. Nevertheless, mounting concerns about the negative environmental impacts of pesticides have spurred efforts to reduce their usage by farmers. Three trials conducted in Iran evaluated the use of the different herbicides, adjuvant and herbicide mixture for weed control in wheat crop. A range of herbicides type, herbicides mixture and adjuvants were evaluated. The following parameters about weeds, including weed density and weed biomass (m-2) were recorded 30 days after spray within 0.5 m2 quadrats (two quadrats per plot), randomly selected from two different locations from each plot. To obtain the grain yields per plot, researchers harvested the grains from the center six rows of each test site, then converted the measurements to ton/ha and weed count per unit area. The results show that herbicides have a significant effect on weed density and weed dry weight comparison with weed control in three years. The maximum weed efficiency (98%) was recorded for Lintur® 70% WG as the first year, second year the maximum weed efficiency was Everest 2.0® plus Cutivate® adjutant and in the third year the maximum weed efficiency (83%) was recorded for Topik® + Bromicide MA®. In conclusion, results of this experiment showed that Lintur, Everest or Topic + Bromicide can be used for weed control in Iran.