Research Info

Title
Epinephrine electrochemical sensor based on a carbon paste electrode modified with hydroquinone derivative and graphene oxide nanosheets: Simultaneous determination of epinephrine, acetaminophen and dopamine
Type Article
Keywords
Modified electrode, Electrochemical sensor, Electrocatalytic oxidation, Epinephrine, Graphene oxide, Acetaminophen, , Dopamine
Abstract
In this paper, an electrochemical sensor was constructed for determination of epinephrine based on carbon paste electrode (CPE) modified with graphene oxide (GO) and 2-(5-Ethyl-2,4-dihydroxyphenyl)-5,7- dimethyl-4H-pyrido[2,3-d][1,3]thiazine-4-one (EDDPT) as modifiers. The modified electrode was applied as an electrochemical sensor for oxidation of epinephrine (EP). Under the optimum conditions, the over potential of EP oxidation decreased about 279 mV at the modified CPE more than a non-modified CPE. Electrochemical behavior of EP was investigated on the fabricated electrode by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods, and some kinetic parameters of EP were obtained, too. The linear range and the detection limit for EP were found to be 1.5–600.0 lM and 0.65 lM (based on 3 s/m), respectively using the EDDPT/GO/CPE sensor and the differential pulse voltammetry (DPV) method. Also, the designed electrochemical sensor was applied to determine EP in the drug sample and simultaneous determination of epinephrine (EP), acetaminophen (AC) and dopamine (DA) in human serum solutions.
Researchers Marzieh Dehghan Tezerjani (First researcher)
ali Benvidi (Second researcher)
Fateme Afsari (Third researcher)
Mohammad Mazloum-Ardakani (Fourth researcher)
ali akbari (Fifth researcher)