Keywords
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Pt nanoparticles, catalysis, tyramine, levodopa, multi-walled carbon nanotube
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Abstract
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Abstract—A multicomponent electrochemical sensor, with two nanometer-scale components in sensing
matrix/electrode, was used to simultaneous determination of levodopa (LD) and tyramine (TR) in pharmaceutical
and diet samples. Multiwall carbon nanotubes (MWCNTs) were used as carbonaceous materials in
the electrode construction. 5-amino-3',4'-dimethoxy-biphenyl-2-ol (5ADMB) was used as electron mediator
and Pt nanoparticles (nPt) as a catalyst. The 5ADMB catalyzes the oxidation of LD to the corresponding
catecholamine, which is electrochemically reduced back to LD. Preparation of this electrode was very simple
and modified electrode showed good properties at electrocatalytic oxidization of LD and TR. Using differential
pulse voltammetry (DPV), a highly selective and simultaneous determination of LD and TR has been
explored at the modified electrode. Differential pulse voltammetry peak currents of LD and TR increased linearly
with their concentrations at the ranges of 0.50–100.0 μM and 0.60–100.0 μM, respectively. Also, the
detection limits for LD and TR were 0.31 and 0.52 μM, respectively. The electrode exhibited an efficient catalytic
response with good reproducibility and stability.
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