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Title
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Anti-bacterial behavior of 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-
hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione against S-mutan bacteria by docking method
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Abstract
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The interaction of the 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4-
b]quinolone-3,5(6H)-dione with S-mutan bacteria was investigated. The docking data confirmed that 4-
cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione has antibacterial behavior and forms strong bond contacts with S- mutan bacteria. The docking energy for S- mutan @ 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione was calculated 8.77 kcal/mol. Drug data was obtained for 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-
hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione
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