Research Info

Title
Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation
Type Article
Keywords
Carbon-carbon coupling, benzofuran, acetylcholinesterase, Alzheimer’s disease
Abstract
A series of biologically active disubstituted benzofuran derivatives (3a– d) have been designed and synthesized via C-H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compounds 3d moderately inhibited AChE activities with 68.12 % values
Researchers Behjat Pouramiri (First researcher)
Mahboobeh Zahedifar (Second researcher)
Adileh Ayati (Third researcher)
Farah Pouramiri (Fourth researcher)
MAHDIYEH AHMADI (Fifth researcher)