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Keywords
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marbling, curation pathway for cow, signaling pathway, improve breeding selection,
transcriptomics profiling
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Abstract
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Red meat is an important dietary source that provides part of the nutritional requirements.
Intramuscular fat, known as marbling, is located throughout skeletal muscle. Marbling is a
trait of major economic relevance that positively influences sensory quality aspects. The
aim of the present study was to identify and better understand biological pathways defining
marbling in beef cattle. Pathway analysis was performed in PathVisio with publicly available
transcriptomic data from semitendinosus muscle of well-marbled and lean-marbled beef.
Moreover, for Bos taurus we created a gene identifier mapping database with bridgeDb
and a pathway collection in WikiPathways. The regulation of marbling is possibly the result
of the interplay between signaling pathways in muscle, fat, and intramuscular connective
tissue. Pathway analysis revealed 17 pathways that were significantly different between
well-marbled and lean-marbled beef. The MAPK signaling pathway was enriched, and the
signaling pathways that play a role in tissue development were also affected. Interestingly,
pathways related to immune response and insulin signaling were enriched.
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