University of Jiroft | Mahboobeh Zahedifar

Research

Title	A Remarkable Bismuth Nitrate-Catalyzed: Rapid Three-Component Synthesis of Pyrimidinone Derivatives
Type	Presentation
Keywords	Bismuth(III) nitrate pentahydrate, Amidines, Pyrimidinones
Researchers	Mahboobeh Zahedifar, Hassan Sheibani, razieh razavi

Abstract

Pyrimidine derivatives have occupied an important position in natural and synthetic organic chemistry, due to their wide range of biological activities particularly in cancer and virus researches[1]. Herein we report a facile and improved protocol for preparation of pyrimidinone derivatives via threecomponent reaction of aldehydes, N-unsubstitutedamidines, and ethyl cyanoacetate under thermal aqueous conditions in the presence of Bismuth nitrate pentahydrate as catalyst. (Scheme 1)