University of Jiroft | Mahboobeh Zahedifar

Research

Title	Rapid three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of Bi(NO3)35H2O as a mild and highly efficient catalyst
Type	Article
Keywords	Bismuth(III) nitrate pentahydrate Amidines Malononitrile 4-Amino-5-pyrimidine-carbonitrile and pyrimidinones
Researchers	Mahboobeh Zahedifar, Hassan Sheibani

Abstract

Bismuth(III) nitrate pentahydrate is found as a mild and highly efficient catalyst for the rapid synthesis of 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives via three-component reaction of aldehydes, N-unsubstituted amidines, and malononitrile or ethyl cyanoacetate under thermal aqueous conditions. The reaction protocol is rapid and simple which is followed by formation of the corresponding pyrimidine and pyrimidinone derivatives in good to excellent yields with high purity