University of Jiroft | Mahboobeh Zahedifar

Research

Title	Reaction of α-oxoketenes with 2-substituted benzothiazoles and benzimidazoles: synthesis of benzo[4,5]thiazolo[3,2-a]pyridinone and N-(1,3-benzothiazol-2-yl)-3-oxopropanamide derivatives
Type	Article
Keywords	chlorocarbonyl phenyl ketene, 1,3-dioxin-4-ones, Meldrum's acids, α-oxoketenes, 2-substituted benzothiazoles.
Researchers	Mahboobeh Zahedifar, Hassan Sheibani

Abstract

A fast and simple procedure for the synthesis of pyrimidinone derivatives via the cyclocondensation reactions of α-oxoketenes with 2-substituted benzothiazoles have been investigated. Acyl-substituted Meldrum's acids and 1,3-dioxin-4-one derivatives have been used as starting compounds for preparation of α-oxoketenes, which were used in the cycloaddition reactions with (benzothiazol-2-yl)- acetonitrile and (benzimidazol-2-yl)acetonitrile giving good product yields. Also the reaction of (chlorocarbonyl)phenylketene with 2-(1,3-benzothiazol-2-yl)acetonitrile has been investigated.