University of Jiroft | Mahboobeh Zahedifar

Research

Title	Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation
Type	Article
Keywords	Carbon-carbon coupling, benzofuran, acetylcholinesterase, Alzheimer’s disease
Researchers	Behjat Pouramiri, Mahboobeh Zahedifar, Adileh Ayati, Farah Pouramiri, MAHDIYEH AHMADI

Abstract

A series of biologically active disubstituted benzofuran derivatives (3a– d) have been designed and synthesized via C-H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compounds 3d moderately inhibited AChE activities with 68.12 % values