1,3-Propanediaminium methanesulfonate [(PDA) (MeSO3)] was synthesized as the first nanoaliphatic ammonium salt via a safe and simple chemical route in aqueous media. [(PDA)(MeSO3)] ammonium salt was characterized by XRD, TEM, SEM, EDS, DLS, AFM, 1H NMR, 13C NMR, FT-IR, TG, and elemental analysis. [(PDA)(MeSO3)] ammonium salt was efficiently applied as an eco-friendly and recyclable organocatalyst for the one-pot, three-component synthesis of 2-amino-3-cyano-4H-pyran derivatives. From an economical and environmental point of view, this novel catalyst has the merits of environmental friendliness, high yields, shorter reaction time, simple work-up, easy operation, the avoidance of the organic solvents, and inexpensive catalysts.