Mahboube Shirani

the present study, a magnetic nano gel as the sorbent which is the combination of octatonic acid: cumarin as eutectic solvent and Fe3O4@ SiO2 was introduced as the sorbent in ultrasound-assisted dispersive μ-solid phase extraction process coupled with high performance liquid chromatography with photo diode array detector for simultaneous separation and determination of tetracyclines residues in food samples. FT-IR, SEM, VSM were used for the characterization of the synthetized magnetic nano gel. Under obtained optimum conditions, the obtained linear ranges were 1.5–500 (μg L− 1), 2.5–750 (μg L− 1), 2–750 (μg L− 1), and 2.5–500 (μg L− 1) for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. Moreover, the below level of quantification (BLQ) (based on S/N = 3) of 0.47 μg L− 1, 0.11 μg L− 1, 0.85 μg L− 1, 0.66 μg L− 1, 0.81 μg L− 1 and the limit of quantification (based on S/N = 10) of 1.61, 2.74, 2.23 (μg L− 1), and 2.66 were achieved for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. The intra-day and inter-day precision (%) of the procedure were less than 3.2 and 3.8, respectively. The recoveries over 95% confirmed high sufficiency of the proposed method for application in complex matrices such as honey, milk, and egg.