In this study, the packed sorbent solid phase (micro) extraction methods from manual to automated modes are
reviewed. The automatic methods have several remarkable advantages such as high sample throughput,
reproducibility, sensitivity, and extraction efficiency. These methods include solid-phase extraction, pipette tip
micro-solid phase extraction, microextraction by packed sorbent, in-tip solid phase microextraction, in-tube solid
phase microextraction, lab-on-a-chip, and lab-on-a-valve. The recent application of these methods for the
extraction of organic and inorganic compounds are discussed. Also, the combination of novel technologies (3D
printing and robotic platforms) with the (semi)automated methods are investigated as the future trend.