Water contamination by heavy metals is one of the environmental issues globally. Thus, the prepared MoS2@CuFe2O4 nanocomposite is effectively utilized to potentially treat manganese from industrial effluents at pH 8 in this study. The impact of significant factors such as pH effect, initial concentration effect, mass of sorbent, and time effect was examined. The results displayed that MoS2@CuFe2O4 nanocomposite was a profitable, efficient, and economically achievable sorbent for potential wastewater treatment.