Fereshteh Ezzatighadi

Gamma irradiation has been recognized as a reliable and safe method for improving the bio-components of plants [1]. The aims of this study were to evaluate the effect of irradiated chicory root extract on liver necrosis. Twenty four adult male Wistar rats were divided equally in six treatments group. Group I) Control, Group II) CCl4, Group III) CCl4+ irradiated chicory root extract, Group IV) CCl4+ chicory root extract, Group V) irradiated chicory root extract and Group VI) chicory root extract. Animals were treated for time duration of 4 weeks. At the end of the study catalase (CAT), superoxide dismutase (SOD), lipid peroxidation (LPO) were evaluated. SOD and CAT levels were decreased in CCl4 treated rats. Whatever, results shows that LPO level were increased in ccl4 treated rats. Result shows that the elevated level of LPO in CCL4 group was decreased by irradiated chicory and chicory root extract.Also, CAT and SOD levels were increased in Group III and IV. Moreover, results shows that the irradiated chicory roots are more effective than non-irradiated chicory. In conclusion, Gamma ray can increase bioactive component of chicory root and is more effective in scavenging free radicals which cause liver necrosis in CCL4 treated group.