عبدالله رمضانی قرا

ABSTRACT Antitumor monoclonal antibodies have shown clinical promise as cancer cell surface targeting agents. The aims of this study was to evaluate the conformational study of the some cell surface targeting peptide which can be used in multiple myeloma treatment. The conformational structure of the 6-mer peptide of YIHYIF in different forms has been investigated by the PCILO method. The computational results revealed that the peptide which blocked it’s C-terminal and with free N-terminal has better functionality group for bind to M- protein. Thus conformational studies shown that H3N+-YIHYIF-NHMe can be used as cancer cell surface targeting peptide in multiple myeloma.