A new electrochemical sensor for the simultaneous determination of dopamine (DA), acetaminophen (AC), folic acid (FA) and N-acetylcysteine (NAC) is described. The sensor is based on carbon-paste electrode (CPE) modified with 5-amino-3′,4′-dimethyl -biphenyl-2-ol (5ADB) and takes the advantages of carbon nanotubes (CNTs), which makes the modified electrode highly sensitive for the electrochemical detection of these compounds. Under the optimum pH of 7.0, the oxidation of DA occurs at a potential about 170 mV less positive than that of the unmodified CPE. Also, square wave voltammetry was used for the simultaneous determination of DA, AC, FA and NAC at the modified electrode.