The preparation of quinazolin-4(3H)-ones by various organic acids, 2-aminobenzoic acid, and ammonium phosphate in one-pot reactions using phosphorus oxychloride as a catalyst. We disclose a highly efficient phosphorus oxychloride catalyzed for the synthesis of quinazolinones in good to excellent yields. The advantages of this method include simple procedures, easy workup, and readily available and inexpensive starting materials.