University of Jiroft | razieh razavi

Research

Title	Anti-bacterial behavior of 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9- hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione against S-mutan bacteria by docking method
Type	Presentation
Keywords	Docking, Pyrazole, S-mutan, Anti-bacterial, Chemical bond.
Researchers	razieh razavi, mahnaz amiri, sayed ali ahmadi

Abstract

The interaction of the 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4- b]quinolone-3,5(6H)-dione with S-mutan bacteria was investigated. The docking data confirmed that 4- cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione has antibacterial behavior and forms strong bond contacts with S- mutan bacteria. The docking energy for S- mutan @ 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9-hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione was calculated 8.77 kcal/mol. Drug data was obtained for 4-cyclopropyl-7,7-dimethyl-2-phenyl-1,2,4,7,8,9- hexahydro-3H-pyrazolo[3,4-b]quinolone-3,5(6H)-dione