راضیه رضوی پاریزی

Pyrimidine derivatives have occupied an important position in natural and synthetic organic chemistry, due to their wide range of biological activities particularly in cancer and virus researches[1]. Herein we report a facile and improved protocol for preparation of pyrimidinone derivatives via threecomponent reaction of aldehydes, N-unsubstitutedamidines, and ethyl cyanoacetate under thermal aqueous conditions in the presence of Bismuth nitrate pentahydrate as catalyst. (Scheme 1)