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Abstract
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The first metal organic framework based on phthalocyanine was synthesized (MOF P). A green
synthesis route was employed to fabricate zinc oxide (ZnO) nanoparticles using Amaranthus
spinosus extract. The as-synthesized ZnO was subsequently integrated into MOF P, yielding a
novel MOF P/ZnO nanocomposite. It was characterized by scanning electron microscopy (SEM),
transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Fourier transform infra-red
spectroscopy (FT-IR), Energy dispersive X-ray analysis (EDAX), elemental analysis, and Ultravioletvisible
(UV-Vis) spectroscopy. This study demonstrates a novel therapeutic platform based on
phthalocyanine-integrated metal-organic frameworks (MOFs) and ZnO nanoparticles for targeted
and efficient cancer therapy. MTT assay results demonstrated a dose-dependent reduction in cell
viability following MOF P/ZnO treatment. Flow cytometry analysis of apoptosis revealed a marked
increase in early and late apoptotic cells. Moreover, ROS levels were significantly elevated in
treated cells.
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