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Abstract
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Duchenne muscular dystrophy (DMD) manifests as a hereditary condition that diminishes
muscular strength through the progressive degeneration of structural muscle tissue, which
is brought about by deficiencies in the dystrophin protein required for the integrity of
muscle cells. DMD is among four different types of dystrophinopathy disorders. Current
studies have established that long non-coding RNAs (lncRNAs) play a significant role in
determining the trajectory and overall prognosis of chronic musculoskeletal conditions.
LncRNAs are different in terms of their lengths, production mechanisms, and operational
modes, but they do not produce proteins, as their primary activity is the regulation of gene
expression. This research synthesizes current literature on the role of lncRNAs in the regulation of myogenesis with a specific focus on certain lncRNAs leading to DMD increments
or suppressing muscle biological functions. LncRNAs modulate skeletal myogenesis gene
expression, yet pathological lncRNA function is linked to various muscular diseases. Some
lncRNAs directly control genes or indirectly control miRNAs with positive or negative
effects on muscle cells or the development of DMD. The research findings have significantly
advanced our knowledge about the regulatory function of lncRNAs on muscle growth and
regeneration processes and DMD diseases
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